PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

Abstract

Chunxia Shi, Pan Cao, Yukun Wang, Qingqi Zhang, Danmei Zhang, Yao Wang, Luwen Wang, Zuojiong Gong Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of ChinaCorrespondence: Zuojiong Gong, Department of Infectious Diseases, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, People’s Republic of China, Email [email protected]: PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.Keywords: PANoptosis, pyroptosis, apoptosis, necroptosis

Keywords

• panoptosis
• pyroptosis
• apoptosis
• necroptosis