Distribution of FoxP3+regulatoryT-cells in rat’spancreatic lymph nodes under streptozotocin-induced diabetes and metformin administration

Abstract

Type 1 diabetes mellitus is a T-cellmediated autoimmune disease characterized by the destruction of β-cells of the pancreas. Numerous studies have demonstrated the key role of FoxP3+ regulatory T-cells in the development of type 1 diabetes. The aim of our study:1) to determine the expression patterns of transcription factor FoxP3 in the pancreatic lymph node cells in animal model of diabetes mellitus and 2) to assay an effect of metformin on these processes. Methods and results.The studywas conducted on 60 male Wistar rats with streptozotocin-induced modeling diabetes with various duration of the diabetes. Within development of type 1 diabetes mellitus the number of Treg pancreatic lymph nodes has been reduced. Conclusion.These findings demonstrate the ability of metformin to increase the number of Treg.

Keywords

• Diabetes mellitus
• FoxP3
• Metformin
• Treg