Nature Communications (Feb 2021)

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

  • Paulino Tallón de Lara,
  • Héctor Castañón,
  • Marijne Vermeer,
  • Nicolás Núñez,
  • Karina Silina,
  • Bettina Sobottka,
  • Joaquín Urdinez,
  • Virginia Cecconi,
  • Hideo Yagita,
  • Farkhondeh Movahedian Attar,
  • Stefanie Hiltbrunner,
  • Isabelle Glarner,
  • Holger Moch,
  • Sònia Tugues,
  • Burkhard Becher,
  • Maries van den Broek

DOI
https://doi.org/10.1038/s41467-021-21045-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a preclinical model.