Nature Communications (Feb 2019)
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads
- Shuyang Chen,
- Changpeng Han,
- Xiao Miao,
- Xin Li,
- Chengqian Yin,
- Junrong Zou,
- Min Liu,
- Shanshan Li,
- Lukasz Stawski,
- Bo Zhu,
- Qiong Shi,
- Zhi-Xiang Xu,
- Chunying Li,
- Colin R. Goding,
- Jun Zhou,
- Rutao Cui
Affiliations
- Shuyang Chen
- Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University
- Changpeng Han
- Yueyang Hospital, Shanghai University of Traditional Chinese Medicine
- Xiao Miao
- Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine
- Xin Li
- Yueyang Hospital, Shanghai University of Traditional Chinese Medicine
- Chengqian Yin
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Junrong Zou
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Min Liu
- Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University
- Shanshan Li
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Lukasz Stawski
- Arthritis Center/Section of Rheumatology, Boston University School of Medicine
- Bo Zhu
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- Qiong Shi
- Department of Dermatology, Xijing Hospital, The Fourth Military Medical University
- Zhi-Xiang Xu
- Division of Hematology and Oncology, Department of Medicine, Comprehensive Care Center, University of Alabama at Birmingham
- Chunying Li
- Department of Dermatology, Xijing Hospital, The Fourth Military Medical University
- Colin R. Goding
- Ludwig Institute for Cancer Research, University of Oxford
- Jun Zhou
- Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, College of Life Sciences, Shandong Normal University
- Rutao Cui
- Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-08691-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Melanocortin-1 receptor is a palmitoylated protein and variants of the receptor are associated with red hair colour and susceptibility to melanoma. Here, the authors describe a method to enhance the palmitoylation of the receptor, which can inhibit melanomagenesis in mice.
