Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein

Benedikt Frieg; James A. Geraets; Timo Strohäker; Christian Dienemann; Panagiota Mavroeidi; Byung Chul Jung; Woojin S. Kim; Seung-Jae Lee; Maria Xilouri; Markus Zweckstetter; Gunnar F. Schröder

doi:10.1038/s42003-022-03948-y

Communications Biology (Sep 2022)

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein

Benedikt Frieg,
James A. Geraets,
Timo Strohäker,
Christian Dienemann,
Panagiota Mavroeidi,
Byung Chul Jung,
Woojin S. Kim,
Seung-Jae Lee,
Maria Xilouri,
Markus Zweckstetter,
Gunnar F. Schröder

Affiliations

Benedikt Frieg: Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
James A. Geraets: Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH
Timo Strohäker: German Center for Neurodegenerative Diseases (DZNE)
Christian Dienemann: Department of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences
Panagiota Mavroeidi: Center of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA) 4
Byung Chul Jung: Department of Biomedical Sciences, Neuroscience Research Institute, College of Medicine, Seoul National University
Woojin S. Kim: Brain and Mind Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney
Seung-Jae Lee: Department of Biomedical Sciences, Neuroscience Research Institute, College of Medicine, Seoul National University
Maria Xilouri: Center of Clinical, Experimental Surgery, & Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA) 4
Markus Zweckstetter: German Center for Neurodegenerative Diseases (DZNE)
Gunnar F. Schröder: Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH

DOI: https://doi.org/10.1038/s42003-022-03948-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

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Quaternary structure of α-synuclein fibrils characterized from human patients with Parkinson’s disease and Multiple System Atrophy modulates seeding in mouse primary oligodendroglial cultures.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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