Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Antoni G. Wrobel; Donald J. Benton; Saira Hussain; Ruth Harvey; Stephen R. Martin; Chloë Roustan; Peter B. Rosenthal; John J. Skehel; Steven J. Gamblin

doi:10.1038/s41467-020-19146-5

Nature Communications (Oct 2020)

Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Antoni G. Wrobel,
Donald J. Benton,
Saira Hussain,
Ruth Harvey,
Stephen R. Martin,
Chloë Roustan,
Peter B. Rosenthal,
John J. Skehel,
Steven J. Gamblin

Affiliations

Antoni G. Wrobel: Structural Biology of Disease Processes Laboratory, Francis Crick Institute
Donald J. Benton: Structural Biology of Disease Processes Laboratory, Francis Crick Institute
Saira Hussain: Worldwide Influenza Centre, Francis Crick Institute
Ruth Harvey: Worldwide Influenza Centre, Francis Crick Institute
Stephen R. Martin: Structural Biology Science Technology Platform, Francis Crick Institute
Chloë Roustan: Structural Biology Science Technology Platform, Francis Crick Institute
Peter B. Rosenthal: Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute
John J. Skehel: Structural Biology of Disease Processes Laboratory, Francis Crick Institute
Steven J. Gamblin: Structural Biology of Disease Processes Laboratory, Francis Crick Institute

DOI: https://doi.org/10.1038/s41467-020-19146-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 5

Abstract

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Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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