Nature Communications (Sep 2017)
Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ
Abstract
Thiopeptides such as nosiheptide are clinically-interesting antimicrobial natural products. Here the authors show the functional dissection of a series of enzymes involved in nosiheptide biosynthesis, revealing a unique biosynthetic pathway that centers on a previously-unknown carrier protein.