Nature Communications (Sep 2017)

Biosynthesis of the nosiheptide indole side ring centers on a cryptic carrier protein NosJ

  • Wei Ding,
  • Wenjuan Ji,
  • Yujie Wu,
  • Runze Wu,
  • Wan-Qiu Liu,
  • Tianlu Mo,
  • Junfeng Zhao,
  • Xiaoyan Ma,
  • Wei Zhang,
  • Ping Xu,
  • Zixin Deng,
  • Boping Tang,
  • Yi Yu,
  • Qi Zhang

DOI
https://doi.org/10.1038/s41467-017-00439-1
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 7

Abstract

Read online

Thiopeptides such as nosiheptide are clinically-interesting antimicrobial natural products. Here the authors show the functional dissection of a series of enzymes involved in nosiheptide biosynthesis, revealing a unique biosynthetic pathway that centers on a previously-unknown carrier protein.