Nature Communications (Jan 2018)
Integrative genomic and transcriptomic analysis of leiomyosarcoma
- Priya Chudasama,
- Sadaf S. Mughal,
- Mathijs A. Sanders,
- Daniel Hübschmann,
- Inn Chung,
- Katharina I. Deeg,
- Siao-Han Wong,
- Sophie Rabe,
- Mario Hlevnjak,
- Marc Zapatka,
- Aurélie Ernst,
- Kortine Kleinheinz,
- Matthias Schlesner,
- Lina Sieverling,
- Barbara Klink,
- Evelin Schröck,
- Remco M. Hoogenboezem,
- Bernd Kasper,
- Christoph E. Heilig,
- Gerlinde Egerer,
- Stephan Wolf,
- Christof von Kalle,
- Roland Eils,
- Albrecht Stenzinger,
- Wilko Weichert,
- Hanno Glimm,
- Stefan Gröschel,
- Hans-Georg Kopp,
- Georg Omlor,
- Burkhard Lehner,
- Sebastian Bauer,
- Simon Schimmack,
- Alexis Ulrich,
- Gunhild Mechtersheimer,
- Karsten Rippe,
- Benedikt Brors,
- Barbara Hutter,
- Marcus Renner,
- Peter Hohenberger,
- Claudia Scholl,
- Stefan Fröhling
Affiliations
- Priya Chudasama
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Sadaf S. Mughal
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Mathijs A. Sanders
- Department of Hematology, Erasmus Medical Center
- Daniel Hübschmann
- Division of Theoretical Bioinformatics, DKFZ
- Inn Chung
- Research Group Genome Organization and Function, DKFZ and BioQuant Center
- Katharina I. Deeg
- Research Group Genome Organization and Function, DKFZ and BioQuant Center
- Siao-Han Wong
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Sophie Rabe
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Mario Hlevnjak
- Division of Molecular Genetics, DKFZ
- Marc Zapatka
- Division of Molecular Genetics, DKFZ
- Aurélie Ernst
- Division of Molecular Genetics, DKFZ
- Kortine Kleinheinz
- Division of Theoretical Bioinformatics, DKFZ
- Matthias Schlesner
- Division of Theoretical Bioinformatics, DKFZ
- Lina Sieverling
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Barbara Klink
- Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technical University Dresden
- Evelin Schröck
- Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technical University Dresden
- Remco M. Hoogenboezem
- Department of Hematology, Erasmus Medical Center
- Bernd Kasper
- Sarcoma Unit, Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, Heidelberg University
- Christoph E. Heilig
- Department of Internal Medicine V, Heidelberg University Hospital
- Gerlinde Egerer
- Department of Internal Medicine V, Heidelberg University Hospital
- Stephan Wolf
- Genomics and Proteomics Core Facility, DKFZ
- Christof von Kalle
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Roland Eils
- Division of Theoretical Bioinformatics, DKFZ
- Albrecht Stenzinger
- German Cancer Consortium (DKTK)
- Wilko Weichert
- Institute of Pathology, Technical University Munich
- Hanno Glimm
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Stefan Gröschel
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Hans-Georg Kopp
- Department of Hematology and Oncology, Eberhard Karls University
- Georg Omlor
- Department of Orthopedics, Heidelberg University Hospital
- Burkhard Lehner
- Department of Orthopedics, Heidelberg University Hospital
- Sebastian Bauer
- Sarcoma Center, Western German Cancer Center
- Simon Schimmack
- Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital
- Alexis Ulrich
- Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital
- Gunhild Mechtersheimer
- Institute of Pathology, Heidelberg University Hospital
- Karsten Rippe
- Research Group Genome Organization and Function, DKFZ and BioQuant Center
- Benedikt Brors
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Barbara Hutter
- Division of Applied Bioinformatics, DKFZ and NCT Heidelberg
- Marcus Renner
- Institute of Pathology, Heidelberg University Hospital
- Peter Hohenberger
- Sarcoma Unit, Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, Heidelberg University
- Claudia Scholl
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Stefan Fröhling
- Division of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-017-02602-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, TP53 and RB1 inactivation, alternative telomere lengthening, and genomic imprints of defective DNA repair via homologous recombination as a potential therapeutic target in LMS patients.
