Journal of Mathematical and Fundamental Sciences (May 2023)

Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)

  • Unang Supratman,
  • Dudi Runadi,
  • Purnama Purnama,
  • Supriatno Salam,
  • Nulelasari Nurlelasari,
  • Desi Harneti,
  • Tri Mayanti,
  • Rani Maharani,
  • Yoshihito Shiono

DOI
https://doi.org/10.5614/j.math.fund.sci.2022.54.3.2
Journal volume & issue
Vol. 54, no. 3

Abstract

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A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11α-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 ± 0.21 mM.

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