Case Reports in Hematology (Jan 2020)

CD7-Positive Diffuse Large B-Cell Lymphoma Presenting as an Intranasal Tumor

  • Kazuaki Teshima,
  • Masaaki Kume,
  • Yasushi Kawaharada,
  • Takashi Saito,
  • Ko Abe,
  • Sho Ikeda,
  • Hideaki Ohyagi,
  • Megumi Zuguchi,
  • Masashi Zuguchi,
  • Yosuke Kubota,
  • Yoshitaka Enomoto,
  • Masahito Miura,
  • Satsuki Takahashi,
  • Masahiro Saito,
  • Ken Saito,
  • Naoto Takahashi

DOI
https://doi.org/10.1155/2020/1514729
Journal volume & issue
Vol. 2020

Abstract

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We report a case of a 74-year-old man with a cluster of differentiation (CD) 7-positive diffuse large B-cell lymphoma (DLBCL) in the right nasal cavity. Flow cytometry analyses showed CD7 and CD20 positivity in tumor cells. The patient received 6 cycles of R-CHOP plus local radiation therapy because positron emission tomography-computed tomography after R-CHOP revealed an intranasal lesion. The patient achieved complete remission (CR) after radiation therapy. The frequency of CD7-positive DLBCL is rare, and only 11 cases with follow-up of clinical course have been reported thus far. CR or partial response was noted in 8 of 11 cases after receiving rituximab combined with chemotherapy. In total, 9 of 12 cases involved the development of extranodal lesions, which occurred as an intranasal tumor in 3 cases. It is important to examine the clinical features by accumulation of further cases.