Journal of the Serbian Chemical Society (Jan 2008)

Benzylation of N-phenyl-2-phenylacetamide under microwave irradiation

  • Mijin Dušan Ž.,
  • Praščević Maša,
  • Petrović Slobodan D.

DOI
https://doi.org/10.2298/JSC0810945M
Journal volume & issue
Vol. 73, no. 10
pp. 945 – 950

Abstract

Read online

N-Phenyl-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide under microwave irradiation in a solvent-free system. The reactions were also performed in the presence of phase-transfer catalysts. The formation of N-, O- and C-products of alkylation was followed by gas chromatography. The N-product was found to be the main product under microwave irradiation. The O-product was obtained in higher yields when an excess of base and benzyl chloride was used.

Keywords