European Journal of Case Reports in Internal Medicine (Jun 2025)

Good’s syndrome revealed by recurrent sigmoid diverticulitis

  • Hassene Attout,
  • Jade Constant,
  • Amel Abdelatif,
  • Guillaume Barry,
  • Olivier Halle

DOI
https://doi.org/10.12890/2025_005480

Abstract

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Thymus is a primary lymphoid organ whose main function is the education of the T lymphocytes. Thymoma is uncommon neoplasia derived from epithelial cells of the thymus. Patients with thymoma frequently present with autoimmune disorders, mostly myasthenia gravis. Good’s syndrome (GS) is an acquired adult-onset combined immunodeficiency typically characterised by the triad of thymoma, hypogammaglobulinaemia and increased susceptibility to recurrent infections. Immunoglobulin replacement is the main therapeutic strategy. Our knowledge of thymoma-associated immunodeficiency is predominantly derived from case reports or small series. We report the case of a patient with recurrent sigmoid diverticulitis that appeared after a thymectomy, who was subsequently found to have severe hypogammaglobulinaemia.

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