Cytotoxic ent-abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalis
Yanisa Olaranont,
Eduard Mas-Claret,
Martin Cheek,
Thomas A.K. Prescott,
Jean Michel Onana,
Moses K. Langat
Affiliations
Yanisa Olaranont
Royal Botanic Gardens Kew, Richmond, TW9 3AE, Surrey, UK; Department of Plant Science, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand
Eduard Mas-Claret
Royal Botanic Gardens Kew, Richmond, TW9 3AE, Surrey, UK
Martin Cheek
Royal Botanic Gardens Kew, Richmond, TW9 3AE, Surrey, UK
Thomas A.K. Prescott
Royal Botanic Gardens Kew, Richmond, TW9 3AE, Surrey, UK
Jean Michel Onana
Department of Plant Biology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon; IRAD-National Herbarium of Cameroon, Yaoundé, PO Box 1601, Cameroon
The chemical investigation of a leaf extract from a herbarium specimen of Suregada occidentalis collected in Banyang Mbo Wildlife Sanctuary, Southwest Region, Cameroon, yielded five undescribed ent-abietane diterpenoids, banyangmbolides A-E, (1–5), and four known diterpenoids, gelomulides A (6), B (7), D (8) and O (9). The structures of the isolated compounds were determined using NMR, IR, ECD and HRESIMS. Compounds 5, 7 and 8, showed 48–55% inhibition at 200 μM against FM-55-M1 human melanoma cells.
