The Aging Male (Dec 2022)

Impact of seminal low-risk human papillomavirus infection on sperm parameters of adult men

  • Rossella Cannarella,
  • Antonio Aversa,
  • Rosita A. Condorelli,
  • Silvia De Cristofaro,
  • Emanuela Greco,
  • Agata Grillo,
  • Aldo E. Calogero,
  • Sandro La Vignera

DOI
https://doi.org/10.1080/13685538.2021.2023126
Journal volume & issue
Vol. 25, no. 1
pp. 17 – 22

Abstract

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Aim: We aimed to evaluate the impact of seminal low-risk human Papillomavirus (LR-HPV) infection on sperm conventional parameters. Material and methods: This was a retrospective case–control study including patients attending to our center for infertility. Patients with evidence for high risk (HR)-HPV infection previously or at the time of enrollment, and/or with severe oligozoospermia (sperm concentration .05). Sperm concentration, total sperm count, sperm progressive motility, morphology, and leukocyte concentration did not differ between patients and controls. However, the prevalence of oligozoospermia was significantly higher in patients than controls (50% vs. 15%). No difference in the prevalence of astenozoospermia (30% vs. 40%) or teratozoospermia (15% vs. 15%) was found. Conclusion: We found no difference in sperm conventional parameters in LR-HPV infected patients than in controls. These data might prompt to research the impact on LR-HPV genotype on male fertility. Particularly, evidence on sperm DNA fragmentation (SDF) and pregnancy outcome is needed.

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