Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

Casimiro Cárdenas; José Antonio Torres-Vargas; Abel Cárdenas-Valdivia; Nuria Jurado; Ana R. Quesada; Melissa García-Caballero; Beatriz Martínez-Poveda; Miguel Ángel Medina

Biomedicine & Pharmacotherapy (Dec 2021)

Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

Casimiro Cárdenas,
José Antonio Torres-Vargas,
Abel Cárdenas-Valdivia,
Nuria Jurado,
Ana R. Quesada,
Melissa García-Caballero,
Beatriz Martínez-Poveda,
Miguel Ángel Medina

Affiliations

Casimiro Cárdenas: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; Research Support Central Services (SCAI) of the University of Málaga, Spain
José Antonio Torres-Vargas: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain
Abel Cárdenas-Valdivia: Department of Physical Chemistry, Faculty of Sciences, University of Malaga, Malaga, Spain
Nuria Jurado: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain
Ana R. Quesada: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga, Spain
Melissa García-Caballero: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain
Beatriz Martínez-Poveda: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain
Miguel Ángel Medina: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain; IBIMA (Biomedical Research Institute of Málaga), E-29071 Málaga, Spain; CIBER de Enfermedades Raras (CIBERER), E-29071 Málaga, Spain; Corresponding author at: Universidad de Málaga, Andalucía Tech, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, E-29071 Málaga, Spain.

Journal volume & issue: Vol. 144
p. 112263

Abstract

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The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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