BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists

Abstract

Key points TLR9 is not only a prognostic biomarker but also a potential target for B-ALL therapy. C-MYC-mediated BAX activation leads to CpG 685-induced apoptosis in B-ALL.

Keywords

• Toll-like receptor 9
• B-cell acute lymphoblastic leukemia
• CpG oligodeoxynucleotide
• Apoptosis
• BAX