Nature Communications (Sep 2019)
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population
- Ryo Takata,
- Atsushi Takahashi,
- Masashi Fujita,
- Yukihide Momozawa,
- Edward J. Saunders,
- Hiroki Yamada,
- Kazuhiro Maejima,
- Kaoru Nakano,
- Yuichiro Nishida,
- Asahi Hishida,
- Keitaro Matsuo,
- Kenji Wakai,
- Taiki Yamaji,
- Norie Sawada,
- Motoki Iwasaki,
- Shoichiro Tsugane,
- Makoto Sasaki,
- Atsushi Shimizu,
- Kozo Tanno,
- Naoko Minegishi,
- Kichiya Suzuki,
- Koichi Matsuda,
- Michiaki Kubo,
- Johji Inazawa,
- Shin Egawa,
- Christopher A. Haiman,
- Osamu Ogawa,
- Wataru Obara,
- Yoichiro Kamatani,
- Shusuke Akamatsu,
- Hidewaki Nakagawa
Affiliations
- Ryo Takata
- Department of Urology, Iwate Medical University
- Atsushi Takahashi
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Masashi Fujita
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Yukihide Momozawa
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
- Edward J. Saunders
- The Institute of Cancer Research
- Hiroki Yamada
- Department of Urology, Jikei University School of Medicine
- Kazuhiro Maejima
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Kaoru Nakano
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Yuichiro Nishida
- Department of Preventive Medicine, Faculty of Medicine, Saga University
- Asahi Hishida
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
- Keitaro Matsuo
- Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Kenji Wakai
- Department of Preventive Medicine, Nagoya University Graduate School of Medicine
- Taiki Yamaji
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Norie Sawada
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Motoki Iwasaki
- Division of Epidemiology, Center for Public Health Sciences, National Cancer Center
- Shoichiro Tsugane
- Center for Public Health Sciences, National Cancer Center
- Makoto Sasaki
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Atsushi Shimizu
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Kozo Tanno
- Iwate Tohoku Medical Megabank Organization, Iwate Medical University
- Naoko Minegishi
- Tohoku Medical Megabank Organization, Tohoku University
- Kichiya Suzuki
- Tohoku Medical Megabank Organization, Tohoku University
- Koichi Matsuda
- Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Johji Inazawa
- Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University
- Shin Egawa
- Department of Urology, Jikei University School of Medicine
- Christopher A. Haiman
- Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California
- Osamu Ogawa
- Department of Urology, Kyoto University Graduate School of Medicine
- Wataru Obara
- Department of Urology, Iwate Medical University
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Shusuke Akamatsu
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Hidewaki Nakagawa
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-019-12267-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
More than 170 genetic loci have been linked to prostate cancer risk, primarily based on genome-wide association studies (GWAS) in European population. Here, the authors performed a GWAS on a Japanese cohort of prostate cancer patients, finding 12 new susceptibility loci, and identifying a polygenic risk for Japanese prostate cancer.
