Nature Communications (Apr 2016)

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

  • Matthew P. Parsons,
  • Matthieu P. Vanni,
  • Cameron L. Woodard,
  • Rujun Kang,
  • Timothy H. Murphy,
  • Lynn A. Raymond

DOI
https://doi.org/10.1038/ncomms11251
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.