Nature Communications (Apr 2016)
Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models
Abstract
Huntington disease (HD) has been linked via biochemical uptake assays to impaired glutamate clearance and resultant excitotoxicity. Here, utilizing a fluorescent reporter, the authors measure real-time glutamate dynamics in mouse model HD brain slices and find normal or even accelerated glutamate clearance.