Journal of Clinical Medicine (Jul 2020)
Child–Adult Transition in Sarcoidosis: A Series of 52 Patients
- Simon Chauveau,
- Florence Jeny,
- Marie-Emeline Montagne,
- Rola Abou Taam,
- Véronique Houdouin,
- Ulrich Meinzer,
- Christophe Delacourt,
- Ralph Epaud,
- Fleur Cohen Aubart,
- Catherine Chapelon-Abric,
- Dominique Israël-Biet,
- Karine Juvin,
- Antoine Dossier,
- Bahram Bodaghi,
- Grégoire Prévot,
- Jean-Marc Naccache,
- Sarah Mattioni,
- Antoine Deschildre,
- Jacques Brouard,
- Abdellatif Tazi,
- Roderich Meckenstock,
- Morgane Didier,
- Julien Haroche,
- Annick Clement,
- Jean-François Bernaudin,
- Hilario Nunes,
- Dominique Valeyre,
- Nadia Nathan,
- for the French Sarcoidosis Group (GSF)
Affiliations
- Simon Chauveau
- AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France
- Florence Jeny
- AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France
- Marie-Emeline Montagne
- AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France
- Rola Abou Taam
- AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Necker Enfants Malades Hospital, 75015 Paris, France
- Véronique Houdouin
- AP-HP Pediatric Pulmonology Department, Robert Debré Hospital, 75019 Paris, France
- Ulrich Meinzer
- AP-HP Department of General Pediatrics, Pediatric Internal Medicine, Rheumatology and Infectious Diseases, National Referee Center for Rare Pediatric Inflammatory Rheumatisms and Systemic Auto-Immune Diseases RAISE, Robert Debré University Hospital, 75019 Paris, France
- Christophe Delacourt
- AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Necker Enfants Malades Hospital, 75015 Paris, France
- Ralph Epaud
- Pediatric Department and Reference Center for Rare Lung Diseases (RespiRare), Centre Hospitalier Intercommunal de Créteil, 94000 Créteil, France
- Fleur Cohen Aubart
- Sorbonne Université, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne 2, French National Reference Center for rare Systemic diseases, 75013-Paris, France
- Catherine Chapelon-Abric
- AP-HP Department of Internal Medicine and Clinical Immunology, La Pitié Salpétrière Hospital, AP-HP, 75013 Paris, France
- Dominique Israël-Biet
- AP-HP Pulmonology Department, HEGP Hospital, 75015 Paris, France
- Karine Juvin
- AP-HP Pulmonology Department, HEGP Hospital, 75015 Paris, France
- Antoine Dossier
- AP-HP Department of Internal Medicine, Bichat Hospital, 75018 Paris, France
- Bahram Bodaghi
- AP-HP Department of Ophtalmology, La Pitié Salpétrière Hospital, IHU FOReSIGHT, Sorbonne Université, 75013 Paris, France
- Grégoire Prévot
- Pulmonology Department, Larrey University Hospital, 31400 Toulouse, France
- Jean-Marc Naccache
- AP-HP Pulmonology Department, Tenon Hospital, 75020 Paris, France
- Sarah Mattioni
- AP-HP Department of Internal Medicine, Tenon Hospital, 75020 Paris, France
- Antoine Deschildre
- Paediatric Pulmonology and Allergy Unit, CHU Lille, Université de lille, Hôpital Jeanne de Flandre, F-59000 Lille, France
- Jacques Brouard
- Pediatric Pulmonology Department, Caen University Hospital, 14000 Caen, France
- Abdellatif Tazi
- AP-HP Pulmonology Department, Saint Louis Hospital, 75010 Paris, France
- Roderich Meckenstock
- Internal Medicine and Infectious Diseases Department, Versailles Hospital, 78150 Le Chesnay, France
- Morgane Didier
- AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France
- Julien Haroche
- Sorbonne Université, Assistance Publique Hôpitaux de Paris, Hôpital de la Pitié-Salpêtrière, Service de Médecine Interne 2, French National Reference Center for rare Systemic diseases, 75013-Paris, France
- Annick Clement
- AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France
- Jean-François Bernaudin
- AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France
- Hilario Nunes
- AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France
- Dominique Valeyre
- AP-HP Pulmonology Department, Avicenne Hospital, 93000 Bobigny, France
- Nadia Nathan
- AP-HP Pediatric Pulmonology Department and Reference Center for Rare Lung Diseases (RespiRare), Armand Trousseau Hospital, 75012 Paris, France
- for the French Sarcoidosis Group (GSF)
- DOI
- https://doi.org/10.3390/jcm9072097
- Journal volume & issue
-
Vol. 9,
no. 7
p. 2097
Abstract
(1) Background: Pediatric sarcoidosis is a rare and mostly severe disease. Very few pediatric series with a prolonged follow-up are reported. We aimed to evaluate the evolution of pediatric sarcoidosis in adulthood. (2) Material and methods: Patients over 18-years-old with a pediatric-onset sarcoidosis (≤15-year-old) who completed at least a three-year follow-up in French expert centers were included. Clinical information at presentation and outcome in adulthood were studied. (3) Results: A total of 52 patients were included (34 prospectively in childhood and 18 retrospectively in adulthood), with a mean age of 12 (±2.7) at diagnosis. The median duration time of follow-up was 11.5 years (range 3–44.5). Relapses mostly occurred during treatment decrease (84.5%), others within the three years after treatment interruption (9.1%), and rarely when the disease was stable for more than three years (6.4%). Sarcoidosis was severe in 11 (21.2%) in adulthood. Patients received a high corticosteroid cumulative dose (median 17,900 mg) for a median duration of five years (range 0–32), resulting in mostly mild (18; 35.3%) and rarely severe (2; 3.8%) adverse events. (4) Conclusions: Pediatric-onset sarcoidosis needed a long-term treatment in almost half of the patients. Around one fifth of pediatric-onset sarcoidosis patients had severe sarcoidosis consequences in adulthood.
Keywords