Association of the rs1966265 and rs351855 <i>FGFR4</i> Variants with Colorectal Cancer in a Mexican Population and Their Analysis In Silico

Abstract

The aim of this study was to associate FGFR4 rs1966265 and rs351855 variants with colorectal cancer (CRC) in a Mexican population and to perform in silico analysis. Genomic DNA from 412 healthy individuals and 475 CRC patients was analyzed. In silico analysis was performed using the PolyPhen-V2, GEPIA, GTEx, and Cytoscape platforms. The GA genotype dominant model (GAAA) of rs1966265 and the AA genotype dominant and recessive models of rs351855 were identified as CRC risk factors (p p p p EFNA4, SLC3A2, and HNF1A share signaling pathways with FGFR4. Therefore, rs1966265 and rs351855 may be potential CRC risk factors.

Keywords

• colorectal neoplasms
• <i>FGFR4</i> gene
• variant
• single nucleotide
• in silico analysis
• genetic variation