Неврология, нейропсихиатрия, психосоматика (Feb 2023)

Association of sleep disorders with various polymorphic variants of the 5-HTTLPR SNP rs25531 A>G gene in people aged 25–44

  • V. V. Gafarov,
  • E. A. Gromova,
  • I. V. Gagulin,
  • D. O. Panov,
  • V. N. Maksimov,
  • M. A. Gubina,
  • A. V. Gafarova

DOI
https://doi.org/10.14412/2074-2711-2023-1-43-49
Journal volume & issue
Vol. 15, no. 1
pp. 43 – 49

Abstract

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Objective: to study the associations between polymorphic variants of the 5-HTTLPR SNP rs25531 A>G gene and sleep disorders in the open population of the able-bodied population aged 25–44 years in Novosibirsk.Material and methods. A representative sample of the population aged 25–44 years in Novosibirsk was surveyed in 2013–2016 (403 men, mean age – 34±0.4 years, response – 71%; 531 women, mean age – 35±0.4 years, response – 72%). The general examination, included in the WHO MONICA-psychosocial (MOPSY) program was carried out according to standard methods. Sleep disturbance was assessed using the Jenkins scale. Three hundred forty nine (349) people who underwent genotyping were selected from the total sample using the method of random numbers generation.Results. In the studied population aged 25–44 years, 42.8% of respondents gave a negative assessment of their sleep, 39.7% of men and 45.3% of women had sleep disorders (χ2 =11.397; df=4; p<0.05). In 19.6% of men and 21.5% of women, sleep duration was 6 hours per day, 5.7% of men and 4.5% of women reported 5 hours of sleep per day (χ2 =2.269; df=5; p>0.05).The most common genotype of the 5-HTTLPR SNP rs25531 A>G gene was SLA (43.3%), LALA (26.4%) was on the second place, SS (17.8%) was on the third place, less represented genotypes in our population were LALG (6.9%), SLG (4.4%), LGLG (1.4%) genotypes.Among individuals with the SLA genotype more common was 5–6 hour sleep (55.3%) (χ2 =4.121; df=1; p<0.05) and 8–10 hour sleep (63.5%) (OR=4.863; 95% CI 1.625–14.555; χ2 =7.625; df=1; p<0.01), among LALA carriers – 8–10 hour sleep (58.5%) (χ2 =4.862; df=1; p< 0.05), compared with carriers of the LALG genotype, among whom 7-hour sleep was more common (73.7%).Conclusion. The effect of the 5-HTTLPR SNP rs25531 A>G gene on serotonin neurotransmission contributes significantly to the etiology of sleep disorders.

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