Features of Bronchial Asthma Course in Children with Concomitant Gastrointestinal Pathology

Abstract

Objective. To examine the influence of concomitant gastrointestinal pathology on the course and control of asthma and cytokine status in children with bronchial asthma. Material and methods. The study included 78 children with asthma and concomitant diseases of upper gastrointestinal tract (I group) and 42 children with asthma without upper gastrointestinal tract pathology (II group). The asthma control was estimated according to GINA, 2009. Serum concentrations of cytokines (IFN-γ and IL-4, IL-5, IL-13) were determined by enzyme-linked immunosorbent assay (test sets Diaclone (France). Results. The children with bronchial asthma often have upper gastrointestinal pathology (65 %) that is accompanied with more severe asthma course and low control of its symptoms, especially in H.рylori identification. The children in the group I were found to have an increased IFN-γ and cytokines serum level involved into allergic inflammatory process (IL-4, IL-5) compared with the group II.

Keywords

• bronchial asthma
• children
• gastrointestinal pathology