Natural sea salt in diet ameliorates better protection compared to table salt in the doxorubicin-induced cardiac remodeling

Abstract

Cardiac dysfunction can be prevented by addressing risk factors including unhealthy diet with other lifestyle modifications. The present study demonstrates the effect of diet mixed with sea and table salts on cardiac remodeling with respect to CKMB, renin, angiotensin II, interleukin-6 and 10. Animals divided into six groups. Normal control, Table salt (0.3%), Natural sea salt (0.3%), Doxorubicin-induced cardiac remodeling control (2 mg/kg), + Normal table salt (0.3%) and Doxorubicin + Natural sea salt (0.3%) . Serum analysis and histopathology of heart, liver and kidney was performed. Significant variation (P < .05) observed in in CKMB for Natural sea salt group compared to Normal. Significant (P < .05) variation in renin for Normal table salt group compared to Normal. Variation in interleukin-6, 10, renin and angiotensin II give new insight in these parameters with marked variation in cellular architecture of the heart, liver and kidney. Observations suggest diet with natural sea salt demonstrated significant beneficial effect on cardiac dysfunction.

Keywords

• Cardiac dysfunction
• sea salt
• table salt
• CKMB
• renin-angiotensin system
• interleukins