TbCAPs: A toolbox for co-activation pattern analysis
Thomas A.W. Bolton,
Constantin Tuleasca,
Diana Wotruba,
Gwladys Rey,
Herberto Dhanis,
Baptiste Gauthier,
Farnaz Delavari,
Elenor Morgenroth,
Julian Gaviria,
Eva Blondiaux,
Lukasz Smigielski,
Dimitri Van De Ville
Affiliations
Thomas A.W. Bolton
Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland; Corresponding author. Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Constantin Tuleasca
Centre Hospitalier Universitaire Bicêtre, Service de Neurochirurgie, Paris, France; Sorbonne Université, Faculté de Médecine, Paris, France; Lausanne University (UNIL), Faculty of Biology and Medicine (FBM), Lausanne, Switzerland; Centre Hospitalier Universitaire Vaudois (CHUV), Neurosurgery Service and Gamma Knife Center, Lausanne, Switzerland
Diana Wotruba
Program for Sustainable Development of Mental Health, University of Zurich, Zurich, Switzerland
Gwladys Rey
Department of Neuroscience, University of Geneva (UNIGE), Geneva, Switzerland
Herberto Dhanis
Laboratory of Cognitive Neuroscience, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Baptiste Gauthier
Laboratory of Cognitive Neuroscience, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Farnaz Delavari
Developmental Imaging and Psychopathology Laboratory, Office Médico-Pédagogique, Department of Psychiatry, University of Geneva (UNIGE), Geneva, Switzerland
Elenor Morgenroth
Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Julian Gaviria
Department of Neuroscience, University of Geneva (UNIGE), Geneva, Switzerland
Eva Blondiaux
Laboratory of Cognitive Neuroscience, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Lukasz Smigielski
Laboratory of Cognitive Neuroscience, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Dimitri Van De Ville
Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva (UNIGE), Geneva, Switzerland
Functional magnetic resonance imaging provides rich spatio-temporal data of human brain activity during task and rest. Many recent efforts have focussed on characterising dynamics of brain activity. One notable instance is co-activation pattern (CAP) analysis, a frame-wise analytical approach that disentangles the different functional brain networks interacting with a user-defined seed region. While promising applications in various clinical settings have been demonstrated, there is not yet any centralised, publicly accessible resource to facilitate the deployment of the technique.Here, we release a working version of TbCAPs, a new toolbox for CAP analysis, which includes all steps of the analytical pipeline, introduces new methodological developments that build on already existing concepts, and enables a facilitated inspection of CAPs and resulting metrics of brain dynamics. The toolbox is available on a public academic repository at https://c4science.ch/source/CAP_Toolbox.git.In addition, to illustrate the feasibility and usefulness of our pipeline, we describe an application to the study of human cognition. CAPs are constructed from resting-state fMRI using as seed the right dorsolateral prefrontal cortex, and, in a separate sample, we successfully predict a behavioural measure of continuous attentional performance from the metrics of CAP dynamics (R = 0.59).
