Real-Time Imaging of Polioviral RNA Translocation across a Membrane

Krishanthi S. Karunatilaka; David J. Filman; Mike Strauss; Joseph J. Loparo; James M. Hogle

doi:10.1128/mBio.03695-20

mBio (Feb 2021)

Real-Time Imaging of Polioviral RNA Translocation across a Membrane

Krishanthi S. Karunatilaka,
David J. Filman,
Mike Strauss,
Joseph J. Loparo,
James M. Hogle

Affiliations

Krishanthi S. Karunatilaka: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
David J. Filman: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
Mike Strauss: Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
Joseph J. Loparo: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
James M. Hogle: ORCiD; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

DOI: https://doi.org/10.1128/mBio.03695-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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The initial transfer of genomic material from a virus into a host cell is a key step in any viral infection. Consequently, understanding how viruses deliver their genomes into cells could reveal attractive therapeutic targets.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal