Particulate matter and their interaction of physical activity on ovarian cancer survival: A prospective cohort study

Ying-Ying Zhang; Yu Li; Meng Luan; Jia-Ming Liu; Ren-Jie Chen; Fan Cao; He-Li Xu; Lang Wu; Dong-Hui Huang; Xiao-Ying Li; Qian Xiao; Sha Ni; Xia Meng; Ting-Ting Gong; Qi-Jun Wu

doi:10.1016/j.ecoenv.2025.118275

Ecotoxicology and Environmental Safety (Jun 2025)

Particulate matter and their interaction of physical activity on ovarian cancer survival: A prospective cohort study

Ying-Ying Zhang,
Yu Li,
Meng Luan,
Jia-Ming Liu,
Ren-Jie Chen,
Fan Cao,
He-Li Xu,
Lang Wu,
Dong-Hui Huang,
Xiao-Ying Li,
Qian Xiao,
Sha Ni,
Xia Meng,
Ting-Ting Gong,
Qi-Jun Wu

Affiliations

Ying-Ying Zhang: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China
Yu Li: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
Meng Luan: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
Jia-Ming Liu: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China
Ren-Jie Chen: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
Fan Cao: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China
He-Li Xu: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China
Lang Wu: Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA
Dong-Hui Huang: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China
Xiao-Ying Li: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China
Qian Xiao: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Medical Insurance Office, Shengjing Hospital of China Medical University, Shenyang, China
Sha Ni: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding authors.
Xia Meng: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; Corresponding authors.
Ting-Ting Gong: Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Corresponding authors.
Qi-Jun Wu: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China; NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University), National Health Commission, Shenyang, China; Corresponding author at: Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.

DOI: https://doi.org/10.1016/j.ecoenv.2025.118275
Journal volume & issue: Vol. 298
p. 118275

Abstract

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Insufficient data exists regarding the trade-off between the survival benefits of exercise in patients with ovarian cancer (OC) and the potential risks associated with increased particulate matter (PM) exposure during physical activity (PA). This study included 822 individuals newly diagnosed with OC. The total PA and subtypes (occupational [OPA], traffic [TPA], household [HPA], leisure-time [LTPA]) were assessed for the year preceding diagnosis using the Physical Activity Questionnaire of the China Kadoorie Biobank. The residential average PM concentrations 1-year before the date of OC diagnosis were assessed by random forest models at a 1 km × 1 km resolution. The comprehensive exposure to three types of PM was evaluated using a PM score (PMS). In addition, we further examined interaction of PMS with different types of PA on OC survival. Cox proportional hazard models were employed to determine hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs). Through a median follow-up of 44.95 months, 373 deaths were documented. The highest tertile of the total PA (HR = 0.68, 95 %CI = 0.53, 0.87), TPA (HR = 0.66, 95 %CI = 0.47, 0.95), HPA (HR = 0.41, 95 %CI = 0.25, 0.67), and LTPA (HR = 0.02, 95 %CI = 0.01, 0.05) showed improved overall survival (OS) compared with the lowest tertile, OPA decreased OS (HR = 1.50, 95 %CI = 1.17, 1.92). Additionally, a 34 % reduction in OC survival was observed with each standard deviation rise in PMS (95 %CI = 1.10, 1.63). Notably, OPA intensified PMS-related OS reductions, while total PA, HPA, and LTPA attenuated this association. We revealed that joint exposure to comprehensive PM was significantly linked to decreased OS of patients with OC, particularly for those primarily engaged in OPA. However, the long-term benefits of total PA, HPA, and LTPA may ameliorate the adverse effects of comprehensive PM exposure during PA.

Published in Ecotoxicology and Environmental Safety

ISSN: 0147-6513 (Print); 1090-2414 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Technology: Environmental technology. Sanitary engineering: Environmental pollution; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/ecotoxicology-and-environmental-safety

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