Healing of Recurrent Aphthous Stomatitis by Non-Thermal Plasma: Pilot Study
Norma Guadalupe Ibáñez-Mancera,
Régulo López-Callejas,
Víctor Hugo Toral-Rizo,
Benjamín Gonzalo Rodríguez-Méndez,
Edith Lara-Carrillo,
Rosendo Peña-Eguiluz,
Regiane Cristina do Amaral,
Antonio Mercado-Cabrera,
Raúl Valencia-Alvarado
Affiliations
Norma Guadalupe Ibáñez-Mancera
Interdisciplinary Center for Health Sciences CICS-UST, Instituto Politécnico Nacional, Av. Luis Enrique Erro S/N, Unidad Profesional Adolfo López Mateos, Zacatenco 07738, Mexico
Régulo López-Callejas
Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Víctor Hugo Toral-Rizo
Orocenter Clinic, Facultad de Odontología, Universidad Autónoma del Estado de México, Av. Paseo Tollocan esq. Jesús Carranza, Colonia Universidad, Toluca de Lerdo 50130, Mexico
Benjamín Gonzalo Rodríguez-Méndez
Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Edith Lara-Carrillo
Orocenter Clinic, Facultad de Odontología, Universidad Autónoma del Estado de México, Av. Paseo Tollocan esq. Jesús Carranza, Colonia Universidad, Toluca de Lerdo 50130, Mexico
Rosendo Peña-Eguiluz
Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Regiane Cristina do Amaral
Departamento de Odontología, Universidade Federal de Sergipe, Aracajú 49060-108, SE, Brazil
Antonio Mercado-Cabrera
Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Raúl Valencia-Alvarado
Plasma Physics Laboratory, Instituto Nacional de Investigaciones Nucleares, Carretera México Toluca S/N, Ocoyoacac 52750, Mexico
Recurrent aphthous stomatitis (RAS) is a common disease in the oral cavity characterized by recurrent ulcers (RU). Usually, these cause acute pain without definitive treatment. The present study determines the efficacy of non-thermal plasma (NTP) for treating RU. NTP is applied to the patient’s RU using a radiofrequency generator connected to a point reactor. The power density applied to the ulcer is 0.50 W/cm2, less than 4 W/cm2, which is the maximum value without biological risk. Each patient received two treatments of three minutes each and spaced 60 min apart at a distance of 5 mm from the RU. From a sample of 30 ulcers in patients treated for RU with an average age of 37 years, they stated that the pain decreased considerably and without the need for ingestion of analgesics and antibiotics. Regeneration took place in an average of three days. The NTP proved to be an excellent therapeutic alternative for the treatment of RU since it has a rapid effect of reducing pain and inflammation, as well as adequate tissue regeneration.
