Nature Communications (Feb 2021)
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
- Riyao Yang,
- Linlin Sun,
- Ching-Fei Li,
- Yu-Han Wang,
- Jun Yao,
- Hui Li,
- Meisi Yan,
- Wei-Chao Chang,
- Jung-Mao Hsu,
- Jong-Ho Cha,
- Jennifer L. Hsu,
- Cheng-Wei Chou,
- Xian Sun,
- Yalan Deng,
- Chao-Kai Chou,
- Dihua Yu,
- Mien-Chie Hung
Affiliations
- Riyao Yang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Linlin Sun
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Ching-Fei Li
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yu-Han Wang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jun Yao
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Hui Li
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Meisi Yan
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Wei-Chao Chang
- Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University
- Jung-Mao Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jong-Ho Cha
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jennifer L. Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Cheng-Wei Chou
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Xian Sun
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yalan Deng
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Chao-Kai Chou
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Dihua Yu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-21099-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism promotes an anti-tumor immune response.
