Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

Antônio Ribeiro de Oliveira, Jr.; Leida Maria Botion; Rachel Menezes Guerra; Rodrigo Bastos Fóscolo; Lucas José Campos Machado; Umeko Marubayashi; Adelina Martha dos Reis; Câ;ndido Celso Coimbra

doi:10.1254/s1347-8613(19)32677-5

Journal of Pharmacological Sciences (Jan 2003)

Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

Antônio Ribeiro de Oliveira, Jr.,
Leida Maria Botion,
Rachel Menezes Guerra,
Rodrigo Bastos Fóscolo,
Lucas José Campos Machado,
Umeko Marubayashi,
Adelina Martha dos Reis,
Câ;ndido Celso Coimbra

Affiliations

Antônio Ribeiro de Oliveira, Jr.: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil; Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Leida Maria Botion: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil
Rachel Menezes Guerra: Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Rodrigo Bastos Fóscolo: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil
Lucas José Campos Machado: Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Umeko Marubayashi: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil
Adelina Martha dos Reis: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil
Câ;ndido Celso Coimbra: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, 6627 Av. Antônio Carlos, 31270-901 Belo Horizonte, Minas Gerais, Brazil

DOI: https://doi.org/10.1254/s1347-8613(19)32677-5
Journal volume & issue: Vol. 92, no. 2
pp. 149 – 152

Abstract

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We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P<0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P<0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P<0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.sciencedirect.com/journal/journal-of-pharmacological-sciences

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