The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites

Jessica O'Reilly; Faith Pangilinan; Karsten Hokamp; Per M. Ueland; John T. Brosnan; Margaret E. Brosnan; Lawrence C. Brody; Anne M. Molloy

Molecular Genetics and Metabolism Reports (Sep 2018)

The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites

Jessica O'Reilly,
Faith Pangilinan,
Karsten Hokamp,
Per M. Ueland,
John T. Brosnan,
Margaret E. Brosnan,
Lawrence C. Brody,
Anne M. Molloy

Affiliations

Jessica O'Reilly: Department of Clinical Medicine, School of Medicine, Trinity College Dublin 2, Ireland
Faith Pangilinan: Genetic and Environmental Interaction Section, National Human Genome Research Institute, Bethesda, MD 20892, United States
Karsten Hokamp: School of Genetics and Microbiology, Trinity College, Dublin 2, Ireland
Per M. Ueland: Section of Pharmacology, Institute of Medicine, University of Bergen and Haukeland University Hospital, 5021 Bergen, Norway
John T. Brosnan: Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
Margaret E. Brosnan: Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
Lawrence C. Brody: Genetic and Environmental Interaction Section, National Human Genome Research Institute, Bethesda, MD 20892, United States; Corresponding author at: 50 South Drive, Room 5306, Bethesda, MD 20892-8004, United States.
Anne M. Molloy: Department of Clinical Medicine, School of Medicine, Trinity College Dublin 2, Ireland

Journal volume & issue: Vol. 16
pp. 20 – 22

Abstract

Read online

The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variation within GCS genes in a sample of young, healthy individuals. Fifty-two variants tagging (r2 < 0.9) the four GCS genes were tested; one variant, GLDC rs2297442-G, was significantly associated (p = .0007) with decreased glycine concentrations in serum. Keywords: Glycine cleavage system (GCS), One-carbon metabolism, Glycine, Folate, Neural tube defects

Published in Molecular Genetics and Metabolism Reports

ISSN: 2214-4269 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: http://www.journals.elsevier.com/molecular-genetics-and-metabolism-reports/

About the journal