Nature Communications (Oct 2017)

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

  • Zhen-Dong Xiao,
  • Leng Han,
  • Hyemin Lee,
  • Li Zhuang,
  • Yilei Zhang,
  • Joelle Baddour,
  • Deepak Nagrath,
  • Christopher G. Wood,
  • Jian Gu,
  • Xifeng Wu,
  • Han Liang,
  • Boyi Gan

DOI
https://doi.org/10.1038/s41467-017-00902-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring.