Frontiers in Oncology (Jan 2022)

Current Progress in Breast Implant-Associated Anaplastic Large Cell Lymphoma

  • Yichen Wang,
  • Qi Zhang,
  • Yufang Tan,
  • Wenchang Lv,
  • Chongru Zhao,
  • Mingchen Xiong,
  • Kai Hou,
  • Min Wu,
  • Yuping Ren,
  • Ning Zeng,
  • Yiping Wu

DOI
https://doi.org/10.3389/fonc.2021.785887
Journal volume & issue
Vol. 11

Abstract

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Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is an uncommon type of T-cell lymphoma. Although with a low incidence, the epidemiological data raised the biosafety and health concerns of breast reconstruction and breast augmentation for BIA-ALCL. Emerging evidence confirms that genetic features, bacterial contamination, chronic inflammation, and textured breast implant are the relevant factors leading to the development of BIA-ALCL. Almost all reported cases with a medical history involve breast implants with a textured surface, which reflects the role of implant surface characteristics in BIA-ALCL. With this review, we expect to highlight the most significant features on etiology, pathogenesis, diagnosis, and therapy of BIA-ALCL, as well as we review the physical characteristics of breast implants and their potential pathogenic effect and hopefully provide a foundation for optimal choice of type of implant with minimal morbidity.

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