Communications Biology (Aug 2022)
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
- Etsuro Nanishi,
- Marisa E. McGrath,
- Timothy R. O’Meara,
- Soumik Barman,
- Jingyou Yu,
- Huahua Wan,
- Carly A. Dillen,
- Manisha Menon,
- Hyuk-Soo Seo,
- Kijun Song,
- Andrew Z. Xu,
- Luke Sebastian,
- Byron Brook,
- Anna-Nicole Bosco,
- Francesco Borriello,
- Robert K. Ernst,
- Dan H. Barouch,
- Sirano Dhe-Paganon,
- Ofer Levy,
- Matthew B. Frieman,
- David J. Dowling
Affiliations
- Etsuro Nanishi
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Marisa E. McGrath
- Department of Microbiology and Immunology, The Center for Pathogen Research, University of Maryland School of Medicine
- Timothy R. O’Meara
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Soumik Barman
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Jingyou Yu
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Huahua Wan
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Carly A. Dillen
- Department of Microbiology and Immunology, The Center for Pathogen Research, University of Maryland School of Medicine
- Manisha Menon
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Hyuk-Soo Seo
- Department of Cancer Biology, Dana-Farber Cancer Institute
- Kijun Song
- Department of Cancer Biology, Dana-Farber Cancer Institute
- Andrew Z. Xu
- Department of Cancer Biology, Dana-Farber Cancer Institute
- Luke Sebastian
- Department of Cancer Biology, Dana-Farber Cancer Institute
- Byron Brook
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Anna-Nicole Bosco
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Francesco Borriello
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Robert K. Ernst
- Department of Microbial Pathogenesis, University of Maryland School of Dentistry
- Dan H. Barouch
- Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
- Sirano Dhe-Paganon
- Department of Cancer Biology, Dana-Farber Cancer Institute
- Ofer Levy
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Matthew B. Frieman
- Department of Microbiology and Immunology, The Center for Pathogen Research, University of Maryland School of Medicine
- David J. Dowling
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- DOI
- https://doi.org/10.1038/s42003-022-03765-3
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 8
Abstract
A longitudinal study in mice reveals that a booster dose of mRNA vaccine BNT162b2 enhances humoral and cell-mediated responses and provides sterilizing immunity against Omicron-induced lung infection in aged animals.
