Thermo-responsive-polymeric-gates of poly(N-isopropylacrylamide)/N-(hydroxymethyl)acrylamide coated magnetic nanoparticles as a synergistic approach to cancer therapy: Drug release and kinetics models of chemothermal magnetic nanoparticles

Abdelrahman I. Rezk; Young-Hwa Kim; Sungkun Chun; Chan Hee Park; Cheol Sang Kim

Materials & Design (Oct 2023)

Thermo-responsive-polymeric-gates of poly(N-isopropylacrylamide)/N-(hydroxymethyl)acrylamide coated magnetic nanoparticles as a synergistic approach to cancer therapy: Drug release and kinetics models of chemothermal magnetic nanoparticles

Abdelrahman I. Rezk,
Young-Hwa Kim,
Sungkun Chun,
Chan Hee Park,
Cheol Sang Kim

Affiliations

Abdelrahman I. Rezk: Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Department of Physiology, Jeonbuk National University Medical School, Jeonju-si 54907, Republic of Korea; BK21FOUR 21st Century Medical Science Creative Human Resource Development Center, Republic of Korea
Young-Hwa Kim: Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 561-756, Republic of Korea
Sungkun Chun: Department of Physiology, Jeonbuk National University Medical School, Jeonju-si 54907, Republic of Korea; BK21FOUR 21st Century Medical Science Creative Human Resource Development Center, Republic of Korea
Chan Hee Park: Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Corresponding authors at: Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea.
Cheol Sang Kim: Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 561-756, Republic of Korea; Corresponding authors at: Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea.

Journal volume & issue: Vol. 234
p. 112350

Abstract

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The study presents a controlled nanoscale drug delivery system mediated by polymeric magnetic nanoparticles. Under an alternating magnetic field (AMF), the magnetic nanoparticles act as internal heating sources that increase the surrounding temperature, provoking polymer transitions and thereby releasing the entrapped drug. We explain the drug-release mechanism using different mathematical models including Higuchi, Korsmeyer–Peppas, Hixson–Crowell, and Kopcha. Our results indicate that doxorubicin (DOX) release follows the Hixson–Crowell model with R2 = 0.99, revealing that the changes in the surface areas of the particles are the main driving force for drug release from poly(N-isopropylacrylamide)/N (hydroxymethyl) acrylamide coated SPIONs (SPNH/DOX) at 43 °C. However, at 37 °C, the drug release occurs by the diffusion mechanism. Moreover, in vitro cell culture assays including CCK-8, FACS, confocal and BIO-TEM images have confirmed cytotoxicity and cellular uptake of SPNH/DOX in CT26 cancer cells. Through a synergetic effect between chemotherapy triggered by AMF application and intracellular hyperthermia, significant tumoricidal effects were achieved in the initial 24 h after treatment.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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