Nature Communications (Sep 2020)
Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor
- Jianlin Liu,
- Ragini Adhav,
- Kai Miao,
- Sek Man Su,
- Lihua Mo,
- Un In Chan,
- Xin Zhang,
- Jun Xu,
- Jianjie Li,
- Xiaodong Shu,
- Jianming Zeng,
- Xu Zhang,
- Xueying Lyu,
- Lakhansing Pardeshi,
- Kaeling Tan,
- Heng Sun,
- Koon Ho Wong,
- Chuxia Deng,
- Xiaoling Xu
Affiliations
- Jianlin Liu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Ragini Adhav
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Kai Miao
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Sek Man Su
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Lihua Mo
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Un In Chan
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xin Zhang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jun Xu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jianjie Li
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xiaodong Shu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Jianming Zeng
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xu Zhang
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xueying Lyu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Lakhansing Pardeshi
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Kaeling Tan
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Heng Sun
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Koon Ho Wong
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Chuxia Deng
- Cancer Centre, Faculty of Health Sciences, University of Macau
- Xiaoling Xu
- Cancer Centre, Faculty of Health Sciences, University of Macau
- DOI
- https://doi.org/10.1038/s41467-020-18637-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Single-cell whole-exome sequencing is a powerful method for deciphering intratumor heterogeneity and identifying cancer drivers. Here, the authors analyze SNVs and CNVs simultaneously in bulk and single cells of BRCA1-associated breast tissues and cancers and show that Plekha5 deficiency promotes metastasis.
