An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

Lin Jin; Xiaoqing Guo; Di Gao; Yan Liu; Jiahua Ni; Zhiming Zhang; Yiqiao Huang; Guibin Xu; Zhe Yang; Xingcai Zhang; Xianhan Jiang

Bioactive Materials (Oct 2022)

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

Lin Jin,
Xiaoqing Guo,
Di Gao,
Yan Liu,
Jiahua Ni,
Zhiming Zhang,
Yiqiao Huang,
Guibin Xu,
Zhe Yang,
Xingcai Zhang,
Xianhan Jiang

Affiliations

Lin Jin: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China; International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, 466001, PR China
Xiaoqing Guo: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China
Di Gao: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China
Yan Liu: School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA
Jiahua Ni: School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA
Zhiming Zhang: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China
Yiqiao Huang: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China
Guibin Xu: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China
Zhe Yang: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China; Research Institute of Xi'an Jiaotong University, Hangzhou, Zhejiang, 311200, PR China; Corresponding author. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, PR China.
Xingcai Zhang: School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA; School of Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Corresponding author. School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Xianhan Jiang: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China; Corresponding author.

Journal volume & issue: Vol. 16
pp. 162 – 172

Abstract

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Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the skin. Herein, we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure, that consists of MXene-loaded nanofibers (MNFs) as the core and dopamine-hyaluronic acid hydrogel (H) as the shell (MNFs@V–H@DA) to encapsulate a growth factor (vascular endothelial growth factor, VEGF, abbreviated as V) and H2S donor (diallyl trisulfide, DATS, abbreviated as DA). The continuous release of DA from this system produced H2S, which would successfully induce macrophages to polarize into M2-lile phenotype, regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound sites. It is conducive to the proliferation of skin cells, facilitating the wound healing. In addition, an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared (NIR) light exposure, preventing excessive neovascularization and extracellular matrix deposition at the wound sites. Collectively, this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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