Cellular Immune Dysfunction in Obstructive Sleep Apnea

Katharina Ludwig; Tilman Huppertz; Markus Radsak; Haralampos Gouveris

doi:10.3389/fsurg.2022.890377

Frontiers in Surgery (Jul 2022)

Cellular Immune Dysfunction in Obstructive Sleep Apnea

Katharina Ludwig,
Tilman Huppertz,
Markus Radsak,
Haralampos Gouveris

Affiliations

Katharina Ludwig: Sleep Medicine Center, Department of Otorhinolaryngology, Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany
Tilman Huppertz: Sleep Medicine Center, Department of Otorhinolaryngology, Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany
Markus Radsak: IIIrd Department of Medicine, Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany
Haralampos Gouveris: Sleep Medicine Center, Department of Otorhinolaryngology, Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany

DOI: https://doi.org/10.3389/fsurg.2022.890377
Journal volume & issue: Vol. 9

Abstract

Read online

Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Repetitive pauses in breathing during sleep cause a brief but recurrent decrease in oxygen saturation in organs and tissues (chronic intermittent tissue hypoxia). Many studies have proven a pro-inflammatory status in OSA patients. However, few reports are available on the effects of OSA on the cellular immune system, mostly focusing on single immune cell types and their subtypes. The aim of this Mini-Review is to summarize these reports, as OSA is associated with a high prevalence and comorbidities such as atherosclerosis, which are known to involve the cellular immune system.

Published in Frontiers in Surgery

ISSN: 2296-875X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Surgery
Website: https://www.frontiersin.org/journals/surgery

About the journal

Abstract

Keywords