Nature Communications (Aug 2018)
Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus
- Doo Hyun Kim,
- Eun-Sook Park,
- Ah Ram Lee,
- Soree Park,
- Yong Kwang Park,
- Sung Hyun Ahn,
- Hong Seok Kang,
- Ju Hee Won,
- Yea Na Ha,
- ByeongJune Jae,
- Dong-Sik Kim,
- Woo-Chang Chung,
- Moon Jung Song,
- Kee-Hwan Kim,
- Seung Hwa Park,
- Soo-Hyun Kim,
- Kyun-Hwan Kim
Affiliations
- Doo Hyun Kim
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Eun-Sook Park
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Ah Ram Lee
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Soree Park
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Yong Kwang Park
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Sung Hyun Ahn
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Hong Seok Kang
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Ju Hee Won
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Yea Na Ha
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- ByeongJune Jae
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- Dong-Sik Kim
- Division of HBP Surgery and Liver Transplantation, Department of Surgery, Korea University College of Medicine
- Woo-Chang Chung
- Virus-Host Interactions Laboratory, Division of Biotechnology, Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University
- Moon Jung Song
- Virus-Host Interactions Laboratory, Division of Biotechnology, Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University
- Kee-Hwan Kim
- Department of Surgery, Uijeongbu St. Mary’s Hospital, Catholic Central Laboratory of Surgery, College of Medicine, The Catholic University of Korea
- Seung Hwa Park
- Department of Anatomy, School of Medicine, Konkuk University
- Soo-Hyun Kim
- Laboratory of Cytokine Immunology, Veterinary School, Konkuk University
- Kyun-Hwan Kim
- Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University
- DOI
- https://doi.org/10.1038/s41467-018-05782-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Cytokines such as TNF and IFN-γ are important for immunity against hepatitis B virus (HBV). Here the authors show that interleukin-32 gamma (IL-32γ) acts downstream of TNF and IFN-γ as an intracellular effector, and that IL-32γ negatively regulates host factors contributing to HBV transcription to promote HBV clearance.
