Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Dongqing Pan; Kai Walstein; Annika Take; David Bier; Nadine Kaiser; Andrea Musacchio

doi:10.1038/s41467-019-12019-6

Nature Communications (Sep 2019)

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Dongqing Pan,
Kai Walstein,
Annika Take,
David Bier,
Nadine Kaiser,
Andrea Musacchio

Affiliations

Dongqing Pan: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Kai Walstein: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Annika Take: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
David Bier: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology
Nadine Kaiser: Department of Chemical Biology, Max Planck Institute of Molecular Physiology
Andrea Musacchio: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology

DOI: https://doi.org/10.1038/s41467-019-12019-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 18

Abstract

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The CENP-A chaperone HJURP associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. Here the authors provide evidence that two repeats in human HJURP previously proposed to be functionally distinct are interchangeable and bind concomitantly to the 4:2:2 Mis18α:Mis18β:M18BP1 complex without dissociating it.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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