Chinese Journal of Lung Cancer (Jul 2022)

Current Progress and Future Developments of Antibody Drug Conjugates 
in Lung Cancer

  • Yixiang ZHU,
  • Zhijie WANG

DOI
https://doi.org/10.3779/j.issn.1009-3419.2022.102.22
Journal volume & issue
Vol. 25, no. 7
pp. 468 – 476

Abstract

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Antibody drug conjugates (ADCs) are a novel class of anti-cancer drugs, which combined the specificity of monoclonal antibodies with the cytotoxic palyload via the linkers. Many ADCs have not only verified impressive activity in a variety of cancers, including breast cancer and hematological system tumors, but also in lung cancer. The aim of this study was to provide informations for practice by summarizing the mechanism of action, clinical application and problems and challenges of ADCs.

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