A new type of DNA phosphorothioation-based antiviral system in archaea

Lei Xiong; Siyi Liu; Si Chen; Yao Xiao; Bochen Zhu; Yali Gao; Yujing Zhang; Beibei Chen; Jie Luo; Zixin Deng; Xiangdong Chen; Lianrong Wang; Shi Chen

doi:10.1038/s41467-019-09390-9

Nature Communications (Apr 2019)

A new type of DNA phosphorothioation-based antiviral system in archaea

Lei Xiong,
Siyi Liu,
Si Chen,
Yao Xiao,
Bochen Zhu,
Yali Gao,
Yujing Zhang,
Beibei Chen,
Jie Luo,
Zixin Deng,
Xiangdong Chen,
Lianrong Wang,
Shi Chen

Affiliations

Lei Xiong: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Siyi Liu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Si Chen: School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University
Yao Xiao: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Bochen Zhu: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Yali Gao: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Yujing Zhang: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Beibei Chen: College of Life Sciences, Wuhan University
Jie Luo: Taihe Hospital, Hubei University of Medicine
Zixin Deng: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Xiangdong Chen: College of Life Sciences, Wuhan University
Lianrong Wang: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University
Shi Chen: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University

DOI: https://doi.org/10.1038/s41467-019-09390-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

The prokaryote defence system Dnd relies on phosphorothioation (PT) of DNA backbone to distinguish between self and non-self DNA. Here, Xiong et al. describe a previously uncharacterized PT-based antiviral system that is independent of the canonical Dnd and is widespread in Archaea and Bacteria.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal