Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation

Shaohui Niu; Haiyan Xiong; Yuan Li; Lihua Zhang

Stem Cell Research (Aug 2020)

Generation of patient-specific induced pluripotent stem cells (ZZUSAHi001-A) derived from a familial atrial fibrillation patient carrying KCNA5 c.775G>A mutation

Shaohui Niu,
Haiyan Xiong,
Yuan Li,
Lihua Zhang

Affiliations

Shaohui Niu: Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Haiyan Xiong: Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Yuan Li: Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Lihua Zhang: Corresponding author at: The Second Affiliated Hospital of Zhengzhou University, Zhengzhou University, Jingba Road No. 2, Jinshui District, Zhengzhou 450052, China.; Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Journal volume & issue: Vol. 47
p. 101915

Abstract

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Peripheral blood mononuclear cells (PBMCs) were isolated from a 57-year-old female who was clinically diagnosed as familial atrial fibrillation and were reprogrammed using non-integrative Sendai viral vectors containing reprogramming factors OCT4, SOX2, KLF4 and cMYC. The generated human induced pluripotent stem cell (hiPSC) line, ZZUSAHi001-A, exhibited a normal karyotype, showed robust expression of pluripotency markers and differentiated towards three germ layers in vivo.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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