Nature Communications (May 2019)
Model-based understanding of single-cell CRISPR screening
- Bin Duan,
- Chi Zhou,
- Chengyu Zhu,
- Yifei Yu,
- Gaoyang Li,
- Shihua Zhang,
- Chao Zhang,
- Xiangyun Ye,
- Hanhui Ma,
- Shen Qu,
- Zhiyuan Zhang,
- Ping Wang,
- Shuyang Sun,
- Qi Liu
Affiliations
- Bin Duan
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- Chi Zhou
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- Chengyu Zhu
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- Yifei Yu
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- Gaoyang Li
- Tongji University Cancer Center, Shanghai Tenth People’s Hospital of Tongji University
- Shihua Zhang
- Institute of Applied Mathematics, Academy of Mathematics and Systems Science
- Chao Zhang
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- Xiangyun Ye
- Shanghai Chest Hospital Shanghai Jiaotong University
- Hanhui Ma
- School of Life Science and Technology ShanghaiTech University
- Shen Qu
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- Zhiyuan Zhang
- Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
- Ping Wang
- Tongji University Cancer Center, Shanghai Tenth People’s Hospital of Tongji University
- Shuyang Sun
- Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
- Qi Liu
- Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Bioinformatics Department, College of Life Science, Tongji University
- DOI
- https://doi.org/10.1038/s41467-019-10216-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Single-cell CRISPR screening combines pooled CRISPR screening with scRNA-seq analysis to expand the resolution power of genetic screening. Here, the authors develop MUSIC, a computational pipeline for analyzing single-cell CRISPR screening data.
