PLoS ONE (Jan 2021)

Epidemiology of heart failure and long-term follow-up outcomes in a north-African population: Results from the NAtional TUnisian REgistry of Heart Failure (NATURE-HF).

  • Leila Abid,
  • Salma Charfeddine,
  • Ikram Kammoun,
  • Manel Ben Halima,
  • Hedi Ben Slima,
  • Meriem Drissa,
  • Khadija Mzoughi,
  • Dorra Mbarek,
  • Leila Riahi,
  • Saoussen Antit,
  • Afef Ben Halima,
  • Wejdene Ouechtati,
  • Emna Allouche,
  • Mehdi Mechri,
  • Chedi Youssfi,
  • Ali Khorchani,
  • Kais Sammoud,
  • Khaled Zaouia,
  • Rami Tlili,
  • Sana Ouali,
  • Faten Triki,
  • Sonia Hamdi,
  • Selim Boudich,
  • Marwa Chebbi,
  • Mouna Hentati,
  • Amani Farah,
  • Habib Triki,
  • H Ghardallou,
  • H Radoui,
  • Sofien Zayed,
  • F Azaiez,
  • Fadoua Omri,
  • Akram Zouari,
  • Zine Ben Ali,
  • A Najjar,
  • Houssem Thabet,
  • Mouna Chaker,
  • Samar Mohammed,
  • Abdelhamid Ben Jmaa,
  • Haithem Tangour,
  • Yassine Kammoun,
  • Mahmoud Cheikh Bouhlel,
  • S Azeiz,
  • R Gtaief,
  • S Mashki,
  • Aymen Amri,
  • Hela Naanea,
  • Raoudha Othmani,
  • Iheb Chahbani,
  • Houcine Zargouni,
  • Syrine Abid,
  • Mokded Ayari,
  • Ines Ben Ameur,
  • Ali Guesmi,
  • Nejeh Ben Halima,
  • Habib Haouala,
  • Wafa Fehri,
  • Essia Boughzela,
  • Lilia Zakhama,
  • Soraya Ben Youssef,
  • Wided Nasraoui,
  • Rachid Boujneh,
  • Nedia Barakett,
  • Sondos Kraiem,
  • Hbiba Drissa,
  • Ali Ben Khalfalah,
  • Habib Gamra,
  • Salem Kachboura,
  • Yosra Majdoub,
  • Elifa Kanoun,
  • Faiez Zannad,
  • Sami Milouchi,
  • Alexandre Mebaza,
  • Samir Kammoun,
  • Sami Mourali,
  • Karima Hezbri,
  • Faouzi Addad

DOI
https://doi.org/10.1371/journal.pone.0251658
Journal volume & issue
Vol. 16, no. 5
p. e0251658

Abstract

Read online

The NATURE-HF registry was aimed to describe clinical epidemiology and 1-year outcomes of outpatients and inpatients with heart failure (HF). This is a prospective, multicenter, observational survey conducted in Tunisian Cardiology centers. A total of 2040 patients were included in the study. Of these, 1632 (80%) were outpatients with chronic HF (CHF). The mean hospital stay was 8.7 ± 8.2 days. The mortality rate during the initial hospitalization event for AHF was 7.4%. The all-cause 1-year mortality rate was 22.8% among AHF patients and 10.6% among CHF patients. Among CHF patients, the older age, diabetes, anemia, reduced EF, ischemic etiology, residual congestion and the absence of ACEI/ ARBs treatment were independent predictors of 1-year cumulative rates of rehospitalization and mortality. The female sex and the functional status were independent predictors of 1-year all-cause mortality and rehospitalization in AHF patients. This study confirmed that acute HF is still associated with a poor prognosis, while the mid-term outcomes in patients with chronic HF seems to be improved. Some differences across countries may be due to different clinical characteristics and differences in healthcare systems.