Nature Communications (May 2019)
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
- Varsha Prakash,
- Brittany B. Carson,
- Jennifer M. Feenstra,
- Randall A. Dass,
- Petra Sekyrova,
- Ayuko Hoshino,
- Julian Petersen,
- Yuan Guo,
- Matthew M. Parks,
- Chad M. Kurylo,
- Jake E. Batchelder,
- Kristian Haller,
- Ayako Hashimoto,
- Helene Rundqivst,
- John S. Condeelis,
- C. David Allis,
- Denis Drygin,
- M. Angela Nieto,
- Michael Andäng,
- Piergiorgio Percipalle,
- Jonas Bergh,
- Igor Adameyko,
- Ann-Kristin Östlund Farrants,
- Johan Hartman,
- David Lyden,
- Kristian Pietras,
- Scott C. Blanchard,
- C. Theresa Vincent
Affiliations
- Varsha Prakash
- Department of Physiology and Pharmacology, Karolinska Institutet
- Brittany B. Carson
- Department of Physiology and Pharmacology, Karolinska Institutet
- Jennifer M. Feenstra
- Department of Physiology and Pharmacology, Karolinska Institutet
- Randall A. Dass
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Petra Sekyrova
- Department of Immunology, Genetics and Pathology, Uppsala University
- Ayuko Hoshino
- Meyer Cancer Center, Weill Cornell Medicine
- Julian Petersen
- Department of Physiology and Pharmacology, Karolinska Institutet
- Yuan Guo
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Matthew M. Parks
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Chad M. Kurylo
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Jake E. Batchelder
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Kristian Haller
- Department of Laboratory Medicine, Center for Molecular Pathology, Lund University
- Ayako Hashimoto
- Meyer Cancer Center, Weill Cornell Medicine
- Helene Rundqivst
- Department of Cell and Molecular Biology, Karolinska Institute
- John S. Condeelis
- Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine
- C. David Allis
- Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
- Denis Drygin
- Pimera, Inc
- M. Angela Nieto
- Instituto de Neurociencias, CSIC-UMH
- Michael Andäng
- Department of Immunology, Genetics and Pathology, Uppsala University
- Piergiorgio Percipalle
- Science Division, Biology Program, New York University Abu Dhabi
- Jonas Bergh
- Department of Oncology and Pathology, Karolinska Institutet and University Hospital
- Igor Adameyko
- Department of Physiology and Pharmacology, Karolinska Institutet
- Ann-Kristin Östlund Farrants
- Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
- Johan Hartman
- Department of Oncology and Pathology, Karolinska Institutet and University Hospital
- David Lyden
- Meyer Cancer Center, Weill Cornell Medicine
- Kristian Pietras
- Department of Laboratory Medicine, Center for Molecular Pathology, Lund University
- Scott C. Blanchard
- Department of Physiology and Biophysics, Weill Cornell Medicine
- C. Theresa Vincent
- Department of Physiology and Pharmacology, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-10100-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Ribosomal DNA transcription is essential for cell growth and division. Here, the authors show that EMT is accompanied by Snail binding to rDNA operons and Rictor association with nucleoli to fuel an induction of ribosome biogenesis during G1/S cell cycle arrest and inhibition of ribosome biogenesis hampers EMT, differentiates primary tumors and reduces metastasis.
