Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

Peipei Li; Lee Marshall; Gabriel Oh; Jennifer L. Jakubowski; Daniel Groot; Yu He; Ting Wang; Arturas Petronis; Viviane Labrie

doi:10.1038/s41467-019-10101-7

Nature Communications (May 2019)

Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer’s disease pathology and cognitive symptoms

Peipei Li,
Lee Marshall,
Gabriel Oh,
Jennifer L. Jakubowski,
Daniel Groot,
Yu He,
Ting Wang,
Arturas Petronis,
Viviane Labrie

Affiliations

Peipei Li: Center for Neurodegenerative Science, Van Andel Research Institute
Lee Marshall: Center for Neurodegenerative Science, Van Andel Research Institute
Gabriel Oh: Centre for Addiction and Mental Health
Jennifer L. Jakubowski: Center for Neurodegenerative Science, Van Andel Research Institute
Daniel Groot: Centre for Addiction and Mental Health
Yu He: Department of Genetics, Washington University in St. Louis
Ting Wang: Department of Genetics, Washington University in St. Louis
Arturas Petronis: Centre for Addiction and Mental Health
Viviane Labrie: Center for Neurodegenerative Science, Van Andel Research Institute

DOI: https://doi.org/10.1038/s41467-019-10101-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Epigenetic control of enhancers may contribute to neurological disease. Here the authors carry out genome-wide analysis of DNA methylation in neurons isolated postmortem from patients with Alzheimer’s disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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