Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase

Yebao Chen; Yongjin Wang; Yang Xu; Jiaojiao Sun; Liu Yang; Chenhao Feng; Jia Wang; Yang Zhou; Zhi-Min Zhang; Yonghua Wang

doi:10.1038/s42004-023-00846-0

Communications Chemistry (Mar 2023)

Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase

Yebao Chen,
Yongjin Wang,
Yang Xu,
Jiaojiao Sun,
Liu Yang,
Chenhao Feng,
Jia Wang,
Yang Zhou,
Zhi-Min Zhang,
Yonghua Wang

Affiliations

Yebao Chen: School of Biology and Biological Engineering, South China University of Technology
Yongjin Wang: International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University
Yang Xu: School of Food Science and Engineering, South China University of Technology
Jiaojiao Sun: School of Food Science and Engineering, South China University of Technology
Liu Yang: School of Food Science and Engineering, South China University of Technology
Chenhao Feng: School of Food Science and Engineering, South China University of Technology
Jia Wang: School of Food Science and Engineering, South China University of Technology
Yang Zhou: International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University
Zhi-Min Zhang: International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University
Yonghua Wang: School of Food Science and Engineering, South China University of Technology

DOI: https://doi.org/10.1038/s42004-023-00846-0
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 7

Abstract

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Phthalate acid ester hydrolases are of promise for the microbial degradation of phthalate acid ester plasticizers, however, only a small number of PAE hydrolases have been characterized. Here, the authors report the structural and functional characterization of MehpH, a monoalkyl phthalate (MBP) hydrolase that degrades MBP to phthalic acid and butanol.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

About the journal