Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

Shin Yajima, MD, PhD; Shigeru Miyagawa, MD, PhD; Satsuki Fukushima, MD, PhD; Yoshiki Sakai, BSc; Hiroko Iseoka, PhD; Akima Harada, BSc; Kayako Isohashi, MD, PhD; Genki Horitsugi, BSc; Yuki Mori, PhD; Motoko Shiozaki, PhD; Hirotatsu Ohkawara, PhD; Ryoto Sakaniwa, PhD; Jun Hatazawa, MD, PhD; Yoshichika Yoshioka, PhD; Yoshiki Sawa, MD, PhD

JACC: Basic to Translational Science (Jun 2019)

Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

Shin Yajima, MD, PhD,
Shigeru Miyagawa, MD, PhD,
Satsuki Fukushima, MD, PhD,
Yoshiki Sakai, BSc,
Hiroko Iseoka, PhD,
Akima Harada, BSc,
Kayako Isohashi, MD, PhD,
Genki Horitsugi, BSc,
Yuki Mori, PhD,
Motoko Shiozaki, PhD,
Hirotatsu Ohkawara, PhD,
Ryoto Sakaniwa, PhD,
Jun Hatazawa, MD, PhD,
Yoshichika Yoshioka, PhD,
Yoshiki Sawa, MD, PhD

Affiliations

Shin Yajima, MD, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Shigeru Miyagawa, MD, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Satsuki Fukushima, MD, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Yoshiki Sakai, BSc: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Hiroko Iseoka, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Akima Harada, BSc: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Kayako Isohashi, MD, PhD: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
Genki Horitsugi, BSc: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
Yuki Mori, PhD: Department of Biofunctional Imaging Laboratory, Immunology Frontier Research Center, Osaka University Graduate School of Medicine, Osaka, Japan
Motoko Shiozaki, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Hirotatsu Ohkawara, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
Ryoto Sakaniwa, PhD: Department of Public Health, Osaka University Graduate School of Medicine, Osaka, Japan
Jun Hatazawa, MD, PhD: Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
Yoshichika Yoshioka, PhD: Department of Biofunctional Imaging Laboratory, Immunology Frontier Research Center, Osaka University Graduate School of Medicine, Osaka, Japan
Yoshiki Sawa, MD, PhD: Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan; Address for correspondence: Dr. Yoshiki Sawa, Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Journal volume & issue: Vol. 4, no. 3
pp. 318 – 331

Abstract

Read online

Summary: Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP–injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution–injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug. Key Words: ischemia/reperfusion injury, nanoparticles, ONO-1301, prostacyclin

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

About the journal