Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism
Xiao-Yu Hu,
Fu-Ying Qin,
Xi-Feng Lu,
Lan-Sheng Zhang,
Yong-Xian Cheng
Affiliations
Xiao-Yu Hu
School of Pharmacy and Chemistry, Dali University, Dali 671000, China
Fu-Ying Qin
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Xi-Feng Lu
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Lan-Sheng Zhang
School of Pharmacy and Chemistry, Dali University, Dali 671000, China
Yong-Xian Cheng
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Three new polyynes, named choushenpilosulynes A–C (1–3), were isolated from an 85% aqueous EtOH extract of the roots of Codonopsis pilosula cultivated in Xundian County of Yunnan province, China. Their structures, including the absolute configuration of the glucose residue in 1 and 2, were determined by spectroscopic analysis and gas chromatography (GC). In addition, biological evaluation shows that all the compounds can inhibit the expression of the squalene monooxygenase (SQLE) gene in HepG2 cells, suggesting that these compounds may be involved in lipid metabolism.
