Nature Communications (Nov 2019)
A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation
Abstract
The hepatopancreatic ductal (HPD) system connects both liver and pancreas to the intestine but the molecular details of HPD development are unclear. Here, the authors describe how regionalised Eph/Ephrin signaling regulates HPD morphogenesis by promoting cellular rearrangements leading to an open tube.